Course Description

The objective of this course is to familiarize students with modern developmental biology and to use this knowledge to understand common human malformations. The course will begin with lectures on the methodology and model systems of developmental biology, a review of preimplantation development and gastrulation, and embryogenesis/organogenesis. Subsequent lectures will focus on the development of several organ systems (e.g. central nervous system, cardiovascular, limb, urogenital, gut/respiratory, and craniofacial). These systems will be covered in two lectures each. A closing lecture on developmental pleiotropy will round out the course.


permission of the course instructor.

Learning Objectives:

  • Connect conceptually the apparently distinct disciplines of embryology, developmental biology, and clinical medicine to appreciate mechanisms of normal and abnormal development
  • Appreciate the role of evolution for understanding the mechanistic basis of malformations and as a basis for the study of these disorders in animal models
  • Develop skills of integrating data from clinical, anatomic and molecular studies to form a comprehensive description of malformations

Textbook Information

Textbook Information

There is a required textbook for GENE 505 that can be purchased through FAES or on your own. The name of the book is: Human Embryology and Developmental Biology, 6th ed. The fee for the book is $78.99. If you would like to purchase the book through FAES, please register for the section (GENE 505-002) that includes the book. Upon receipt of payment and fulfillment of your book order, your book can be picked up at the FAES Bookstore in Building 10 on the main NIH campus.

If you are unable to pick up the book at the FAES bookstore and would like the book mailed to you, please contact FAES at (301) 496-7976 or registrar@faes.org. There is a $10 charge for mailing the book.

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