The six Hallmarks of Cancer were first presented by Douglas Hanahan and Robert Weinberg in 2000 to organize the complexity of cancer into broader principles based on function. In 2011, the Hallmarks of Cancer were updated to ten to include additional hallmarks based on advances in research in the role of the tumor microenvironment in carcinogenesis. This course will examine each of the ten Hallmarks of Cancer, going into detail about the biological functions and major signaling pathways of each, as well as mechanisms to target them. Overall, an introduction to the hallmarks of cancer will provide an excellent baseline of knowledge about cancer characteristics and why they are targeted for therapy.